NATINUEL Rx50 SYNERGIC PEEL

Why Rx50?

✅ Bio-Energetic Action – Increases cellular energy, accelerates metabolism, and restores biochemical balance in the skin.
✅ Collagen & Elastin Booster – Strengthens the skin’s structural integrity, improving firmness and elasticity.
✅ A True ‘Peel Booster’ – Can be combined with Poli-Soft, Mando Complex, Mando Ferul, or Revinol Peel for customized treatments.
✅ Suitable for All Skin Types – A versatile peel that can be used year-round without downtime.
✅ The Only Peel That Requires Massage – Enhances penetration and activation for maximum effectiveness.

Product leaflet / protocol

RX 50 is a peel. But it works like no other peel you have ever encountered.

A conventional peel has a precise structural limitation: it is aggressive by definition, applied and removed, impossible to massage, incapable of engaging with skin biology. It does one thing — exfoliate — and it does so with controlled violence.

RX 50 redefines this paradigm. It is a peel that can be massaged. That transforms during the treatment. That does not merely loosen the bonds between cells of the stratum corneum (corneodesmosomes), reactivating a natural exfoliation, but delivers energy, substrates and protection to the skin as it renews.

This document explains how and why, in clear and honest language. You will find logic, not promises.

RX 50 arrives in two separate sachets that are mixed at the moment of use. This is not a complication: it is the condition for the product to work.

Sachet A — the structure and the builders

Contains the oil platform (triglycerides, sweet almond oil, grape seed oil) and the structural builders: the amino acids Glycine, Proline and Lysine — the three fundamental building blocks of collagen and elastin — and Phytic Acid, a selective chelator of pro-oxidant metals.

Sachet B — the acid platform

Contains the five active acids — Succinic, Ferulic, Glycolic, Lactic and Pyruvic — dispersed in glycerine and stabilised by a polymeric matrix (POLYACRYLATE CROSSPOLYMER-6) and kaolin.

The extemporaneous preparation is a physicochemical choice, not a commercial one. Kept apart, the components remain stable. United at the moment of use, they generate a dynamic oil-like structure whose bioactivity would be impossible in a pre-formulated product: the amino acids would encounter the acids, react, and lose their function before ever touching the skin.

Here lies the heart of RX 50's innovation. When one speaks of a peel at pH 1.5–1.8, the immediate thought is: it burns, it irritates, it cannot be touched. With a conventional peel, that would be true.

But RX 50 is not an acidic liquid. It is an oil-like structure: the triglycerides, vegetable oils and emulsifiers of Phase A create an oily matrix that envelops and retains the acids of Phase B. The result is a product that can be massaged onto the skin — something impossible with any traditional peel.

The oil-like structure functions as a kinetic barrier: it does not eliminate the acids, but slows the rate at which H⁺ ions make contact with the cells. The overall pH remains that of a professional peel (1.5–1.8), but the contact velocity is entirely different. The skin perceives a modulated intensity, not an assault.

The transformation during treatment

But the oil-like structure does something more: it transforms during the treatment itself.

Phase 1 — Pure oil-like.  Freshly mixed, the product is a dense oily structure. It is applied to the skin and massaged directly. Acid distribution is uniform, cell by cell. No peaks of aggression.

Phase 2 — Damp hands, light emulsion.  When the hands are moistened, the structure converts spontaneously into a fluid, light emulsion. The massage can continue for an extended period, with full comfort and control. Ideal for comprehensive face-neck-décolletage treatments.

This transformation is not a cosmetic detail. It is a genuine operational advantage: you can modulate the treatment's intensity in real time, simply by changing the product's consistency with your hands.

 

 

This is the aspect that makes RX 50 radically different from any peel on the market.

A conventional peel does one thing: it removes. It loosens the bonds between cells of the stratum corneum (corneodesmosomes), and this reactivates a natural exfoliation — renewal restarts. Full stop. But renewal needs energy, substrates and protection — and a conventional peel provides none of these.

RX 50 was designed to do three things simultaneously: remove, deliver and protect.

Remove — intelligent exfoliation

The five acids loosen the corneodesmosomes in a complementary fashion: Glycolic Acid penetrates deeply, Lactic Acid hydrates and encourages gentle detachment, Pyruvic Acid, being lipophilic, penetrates rapidly and promotes desquamation. The resulting exfoliation is controlled and adjustable, not aggressive — because the oil-like structure governs the contact velocity.

Deliver — energy and collagen building blocks

Succinic Acid — cellular fuel.  It is not simply an exfoliating acid. It is a direct substrate of the Krebs cycle: it enters the mitochondrion and generates energy (ATP) through the reaction succinate → fumarate + FADH₂. Whilst the peel renews the surface, Succinic Acid reignites the metabolic engine of the cells beneath.

Glycine + Proline + Lysine — the structural bricks.  These are the three fundamental amino acids of collagen (the repetitive Gly-Pro-X sequence of the triple helix) and of elastin (Lysine forms desmosine, the "elastic hinge"). Supplying them during the peel means delivering substrates to the fibroblasts at the precise moment they are being stimulated by the acids. This is not coincidence: it is by design.

Protect — during renewal

Ferulic Acid — the antioxidant shield.  Cellular renewal generates free radicals (ROS). Ferulic Acid neutralises them as they are produced. Furthermore, it protects cellular DNA and inhibits the activation of NF-κB, the key mediator of inflammation. It does not correct damage afterwards: it prevents it during.

Phytic Acid — the intelligent chelator.  It sequesters pro-oxidant metals — in particular copper, an essential cofactor of tyrosinase. Without copper at the active site, the enzyme cannot produce excess melanin. This is an elegant depigmenting action: it does not bleach; it removes the tool from the process.

In RX 50, every acid has a specific role that complements the others. This is not a sum: it is a team in which each member covers a function the others do not possess.

Pyruvic Acid — the deep penetrator

An alpha-keto acid with high lipophilicity: it penetrates rapidly and deeply. It has a desquamating action (promotes detachment of superficial corneocytes), a stimulating action (improves proliferation and differentiation), a depigmenting action (accelerates turnover of pigmented cells) and a renewing action (activates neo-synthesis of collagen in the dermis). It is also a direct substrate of the Krebs cycle, like Succinic Acid: it delivers metabolic energy to the cells.

Glycolic Acid — the classic, enhanced

The smallest of the alpha-hydroxy acids, with the greatest capacity for transcutaneous penetration. It interacts with intercorneocyte bonds and activates the mechanisms that regulate cellular energy metabolism. In this context, however, it does not work alone: the oil-like structure modulates its release, transforming its aggressiveness into controlled efficacy.

Lactic Acid — the gentle exfoliant

It desquamates gently whilst simultaneously hydrating: it draws water into the stratum corneum through its hydroxyl groups. Ideal for sensitive skin, where renewal without aggression is required. Its synergistic action with Glycolic Acid creates a dual-speed exfoliation: deep and superficial at once.

Succinic Acid — the mitochondrial energiser

A dicarboxylic acid that plays a fundamental role in mitochondrial function. It is part of the respiratory chain and the Krebs cycle: the reaction succinate + FAD → fumarate + FADH₂ donates electrons to the transfer chain. It prevents and counteracts ageing through direct mitochondrial revitalisation. Moreover, it chelates copper at the active site of tyrosinase: a depigmenting action complementary to that of Phytic Acid.

Ferulic Acid — the DNA protector

A phenolic derivative with a high capacity to neutralise superoxide, hydroxyl and nitric oxide radicals. It potentiates the efficacy of antioxidant vitamins C and E, prevents the activation of NF-κB (anti-inflammatory), inhibits tyrosinase (depigmenting) and enhances photoprotection. It is a guardian of cellular DNA that works in synergy with every other component.

This is the function that makes RX 50 unique in the professional landscape.

Once the compound has been reconstituted, the oil-like structure can incorporate other peels into the same blend. It does not layer them: it integrates them into its own structure, stabilises them and modulates their penetration.

The oil-like structure functions as a carrier platform: it distributes added actives uniformly, modulates their release kinetics and amplifies the overall bioactivity of the treatment. A level of personalisation that no pre-formulated peel can offer.

1. Enhanced classical peel.  Apply to cleansed skin, massage in pure oil-like form for several minutes, leave on for a further contact period, then wash thoroughly with cold water. Provides modulated exfoliation with active biochemical renewal.

2. Extended massage.  Begin with dry hands (oil-like structure), then continue by moistening the hands: the structure converts spontaneously into a fluid, light emulsion. The massage can continue at length — ideal for comprehensive face-neck-décolletage protocols, maintaining comfort and control throughout.

3. Personalised blend.  Combine reconstituted RX 50 with a second compatible peel. The oil-like platform integrates and modulates both: a bespoke protocol for every skin type and therapeutic objective.

In all modes, the product is removed with cold water at the end of the treatment. No chemical neutralisation is required.

In a market where every peel promises results and none explains how it achieves them, RX 50 takes the opposite path: it explains everything and lets the results speak.

 

✦   Extemporaneous bi-component preparation — amino acids and acids meet fresh, the structure is alive and dynamic.

✦   Oil-like structure — a kinetic barrier that makes a pH 1.5–1.8 peel massageable. Potency without aggression.

✦   In-treatment transformation — from oil-like to light emulsion with damp hands. Real-time adjustability.

✦   Triple action: remove, deliver, protect — exfoliation + cellular energy + amino acids for collagen + antioxidant shield.

✦   Five complementary acids — Pyruvic, Glycolic, Lactic, Succinic, Ferulic. Every level of the skin is addressed.

✦   Precursor amino acids — Glycine, Proline, Lysine: the building blocks of collagen and elastin, delivered at the right moment.

✦   Phytic Acid chelation — intelligent depigmentation by removing the metallic cofactor of tyrosinase.

✦   Boostable — an open platform that integrates and modulates other peels. A different treatment for every client.